منابع مشابه
Transcription factor access to chromatin.
The question of how sequence-specific transcription factors access their cognate sites in nucleosomally organized DNA is discussed on the basis of genomic footprinting data and chromatin reconstitution experiments. A classification of factors into two categories is proposed: (i) initiator factors which are able to bind their target sequences within regular nucleosomes and initiate events leadin...
متن کاملIntestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.
Tissue-specific gene expression requires modulation of nucleosomes, allowing transcription factors to occupy cis elements that are accessible only in selected tissues. Master transcription factors control cell-specific genes and define cellular identities, but it is unclear if they possess special abilities to regulate cell-specific chromatin and if such abilities might underlie lineage determi...
متن کاملIntestinal Master Transcription Factor Cdx2 Controls Chromatin 1 Access for Partner Transcription Factor Binding 2 3
1 Intestinal master transcription factor CDX2 controls chromatin 1 access for partner transcription factor binding 2 3 Michael P. Verzi*, Hyunjin Shin*, Adrianna K. San Roman, 4 X. Shirley Liu, and Ramesh A. Shivdasani 5 6 7 Department of Medical Oncology and Department of Biostatistics and Computational Biology, 8 Dana-Farber Cancer Institute, Boston, MA 02215 (USA); Departments of Medicine, B...
متن کاملCalculating transcription factor binding maps for chromatin
Current high-throughput experiments already generate enough data for retrieving the DNA sequence-dependent binding affinities of transcription factors (TF) and other chromosomal proteins throughout the complete genome. However, the reverse task of calculating binding maps in a chromatin context for a given set of concentrations and TF affinities appears to be even more challenging and computati...
متن کاملTranscription Elongation: TLKing to Chromatin?
Tousled-like kinases (TLKs) have important functions during the cell cycle in eukaryotes. The TLK family was named after its founding member, the product of the TOUSLED gene which is essential for normal development of the plant Arabidopsis thaliana [1]. More recently, these kinases have been implicated in deposition of chromatin following DNA replication. During S phase, nucleosomes must be as...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 1997
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/25.18.3559